Natasha Frank

Publications

1. MYEOV Is a Novel Marker of Differentiated Corneal Epithelium. Invest Ophthalmol Vis Sci. 2025 Nov 03; 66(14):7. View Abstract
2. Optimal Cannabinoid-Terpene Combination Ratios Suppress Mutagenicity of Gastric Reflux in Normal and Metaplastic Esophageal Cells. bioRxiv. 2025 Sep 25. View Abstract
3. A Rare Heterozygous MYH11 Missense Variant in a Patient With Recurrent Strokes, Intracerebral Arterial Pathology, and Aortic Aneurysm. Cureus. 2025 Sep; 17(9):e91418. View Abstract
4. Caveolin 1 and 2 enhance the proliferative capacity of BCAM-positive corneal progenitors. Sci Rep. 2025 Feb 24; 15(1):6672. View Abstract
5. Anti-Inflammatory and Anti-(Lymph)angiogenic Properties of an ABCB5+ Limbal Mesenchymal Stem Cell Population. Int J Mol Sci. 2024 Sep 07; 25(17). View Abstract
6. Processes and outcomes from a clinical genetics e-consultation service managed by a primary care physician champion. Genet Med Open. 2024; 2:101831. View Abstract
7. Accelerated Aging and Microsatellite Instability in Recessive Dystrophic Epidermolysis Bullosa-Associated Cutaneous Squamous Cell Carcinoma. J Invest Dermatol. 2024 Jul; 144(7):1534-1543.e2. View Abstract
8. Protocol for isolating human BCAM-positive corneal progenitor cells by flow cytometry and cell sorting. STAR Protoc. 2023 09 15; 4(3):102503. View Abstract
9. Corrigendum to ABCB5+ mesenchymal stromal cells facilitate complete and durable wound closure in recessive dystrophic epidermolysis bullosa [Cytotherapy 25 (2023) 782-788/1562]. Cytotherapy. 2023 Sep; 25(9):1016. View Abstract
10. Variable ventilation ages in the equatorial Indian Ocean thermocline during the LGM. Sci Rep. 2023 Jul 13; 13(1):11355. View Abstract
11. ABCB5+ Limbal Epithelial Stem Cells Inhibit Developmental but Promote Inflammatory (Lymph) Angiogenesis While Preventing Corneal Inflammation. Cells. 2023 06 27; 12(13). View Abstract
12. ABCB5+ mesenchymal stromal cells facilitate complete and durable wound closure in recessive dystrophic epidermolysis bullosa. Cytotherapy. 2023 07; 25(7):782-788. View Abstract
13. Epigenetic Regulation of Corneal Epithelial Differentiation by TET2. Int J Mol Sci. 2023 Feb 02; 24(3). View Abstract
14. ATF-3 expression inhibits melanoma growth by downregulating ERK and AKT pathways. Lab Invest. 2021 May; 101(5):636-647. View Abstract
15. Skin-Derived ABCB5+ Mesenchymal Stem Cells for High-Medical-Need Inflammatory Diseases: From Discovery to Entering Clinical Routine. Int J Mol Sci. 2022 Dec 21; 24(1). View Abstract
16. Consecutive dosing of UVB irradiation induces loss of ABCB5 expression and activation of EMT and fibrosis proteins in limbal epithelial cells similar to pterygium epithelium. Stem Cell Res. 2022 10; 64:102936. View Abstract
17. Translational development of ABCB5+ dermal mesenchymal stem cells for therapeutic induction of angiogenesis in non-healing diabetic foot ulcers. Stem Cell Res Ther. 2022 09 05; 13(1):455. View Abstract
18. Limbal BCAM expression identifies a proliferative progenitor population capable of holoclone formation and corneal differentiation. Cell Rep. 2022 08 09; 40(6):111166. View Abstract
19. Clinical trial of ABCB5+ mesenchymal stem cells for recessive dystrophic epidermolysis bullosa. JCI Insight. 2021 11 22; 6(22). View Abstract
20. Angiogenin Released from ABCB5+ Stromal Precursors Improves Healing of Diabetic Wounds by Promoting Angiogenesis. J Invest Dermatol. 2022 06; 142(6):1725-1736.e10. View Abstract
21. Allogeneic ABCB5+ mesenchymal stem cells for treatment-refractory chronic venous ulcers: a phase I/IIa clinical trial. JID Innov. 2022 Jan; 2(1). View Abstract
22. High expression of SARS-CoV2 viral entry-related proteins in human limbal stem cells. Ocul Surf. 2022 01; 23:197-200. View Abstract
23. Human iPS cells engender corneal epithelial stem cells with holoclone-forming capabilities. iScience. 2021 Jun 25; 24(6):102688. View Abstract
24. Process development and safety evaluation of ABCB5+ limbal stem cells as advanced-therapy medicinal product to treat limbal stem cell deficiency. Stem Cell Res Ther. 2021 03 19; 12(1):194. View Abstract
25. ABCB5+ dermal mesenchymal stromal cells with favorable skin homing and local immunomodulation for recessive dystrophic epidermolysis bullosa treatment. Stem Cells. 2021 07; 39(7):897-903. View Abstract
26. Clinical Implications of Colorectal Cancer Stem Cells in the Age of Single-Cell Omics and Targeted Therapies. Gastroenterology. 2021 05; 160(6):1947-1960. View Abstract
27. ATF-3 expression inhibits melanoma growth by downregulating ERK and AKT pathways. Lab Invest. 2021 05; 101(5):636-647. View Abstract
28. Ex vivo-expanded highly pure ABCB5+ mesenchymal stromal cells as Good Manufacturing Practice-compliant autologous advanced therapy medicinal product for clinical use: process validation and first in-human data. Cytotherapy. 2021 02; 23(2):165-175. View Abstract
29. Targeting the ABC transporter ABCB5 sensitizes glioblastoma to temozolomide-induced apoptosis through a cell-cycle checkpoint regulation mechanism. J Biol Chem. 2020 05 29; 295(22):7774-7788. View Abstract
30. Metabolic modeling using statistical and spreadsheet software: Application to the glucose minimal model. Comput Methods Programs Biomed. 2020 Jul; 191:105353. View Abstract
31. Loss of the Epigenetic Mark 5-hmC in Psoriasis: Implications for Epidermal Stem Cell Dysregulation. J Invest Dermatol. 2020 06; 140(6):1266-1275.e3. View Abstract
32. Investigation of factors associated with ABCB5-positive limbal stem cell isolation yields from human donors. Ocul Surf. 2020 01; 18(1):114-120. View Abstract
33. Newly Defined ATP-Binding Cassette Subfamily B Member 5 Positive Dermal Mesenchymal Stem Cells Promote Healing of Chronic Iron-Overload Wounds via Secretion of Interleukin-1 Receptor Antagonist. Stem Cells. 2019 08; 37(8):1057-1074. View Abstract
34. Diagnosis and treatment of confirmed and suspected primary hyperparathyroidism in equids: 17 cases (1999-2016). Equine Vet J. 2020 Jan; 52(1):83-90. View Abstract
35. In vivo safety profile and biodistribution of GMP-manufactured human skin-derived ABCB5-positive mesenchymal stromal cells for use in clinical trials. Cytotherapy. 2019 05; 21(5):546-560. View Abstract
36. Homozygous TRPV4 mutation causes congenital distal spinal muscular atrophy and arthrogryposis. Neurol Genet. 2019 Apr; 5(2):e312. View Abstract
37. An integrated clinical program and crowdsourcing strategy for genomic sequencing and Mendelian disease gene discovery. NPJ Genom Med. 2018; 3:21. View Abstract
38. ATP-binding cassette member B5 (ABCB5) promotes tumor cell invasiveness in human colorectal cancer. J Biol Chem. 2018 07 13; 293(28):11166-11178. View Abstract
39. Repairing the corneal epithelium using limbal stem cells or alternative cell-based therapies. Expert Opin Biol Ther. 2018 05; 18(5):505-513. View Abstract
40. Limbal stem cells: identity, developmental origin, and therapeutic potential. Wiley Interdiscip Rev Dev Biol. 2018 03; 7(2). View Abstract
41. Vitamin D and probiotics supplement use in young children with genetic risk for type 1 diabetes. Eur J Clin Nutr. 2017 12; 71(12):1449-1454. View Abstract
42. Rapid generation of Col7a1-/- mouse model of recessive dystrophic epidermolysis bullosa and partial rescue via immunosuppressive dermal mesenchymal stem cells. Lab Invest. 2017 10; 97(10):1218-1224. View Abstract
43. Reply. J Allergy Clin Immunol. 2017 05; 139(5):1720-1721. View Abstract
44. Brain MRS glutamine as a biomarker to guide therapy of hyperammonemic coma. Mol Genet Metab. 2017 05; 121(1):9-15. View Abstract
45. The novel MKL target gene myoferlin modulates expansion and senescence of hepatocellular carcinoma. Oncogene. 2017 06 15; 36(24):3464-3476. View Abstract
46. Clinical Significance of Disseminated Pluripotent Tumor Cell Signature Expression in the Bone Marrow from Patients with Colorectal Cancer. J Cancer Sci Ther. 2017; 9(10):669-674. View Abstract
47. Deficiency of the immunostimulatory cytokine IL-21 promotes intestinal neoplasia via dysregulation of the Th1/Th17 axis. Oncoimmunology. 2017; 6(1):e1261776. View Abstract
48. Dissecting a Case of Abdominal Pain. N Engl J Med. 2016 10 27; 375(17):e35. View Abstract
49. In Vivo Development of Transplant Arteriosclerosis in Humanized Mice Reflects Alloantigen Recognition and Peripheral Treg Phenotype of Lung Transplant Recipients. Am J Transplant. 2016 11; 16(11):3150-3162. View Abstract
50. Loss of function mutation in LOX causes thoracic aortic aneurysm and dissection in humans. Proc Natl Acad Sci U S A. 2016 08 02; 113(31):8759-64. View Abstract
51. Suppression of Neutrophil-Mediated Tissue Damage-A Novel Skill of Mesenchymal Stem Cells. Stem Cells. 2016 09; 34(9):2393-406. View Abstract
52. Stromal CCR6 drives tumor growth in a murine transplantable colon cancer through recruitment of tumor-promoting macrophages. Oncoimmunology. 2016 Aug; 5(8):e1189052. View Abstract
53. Multi-color immune-phenotyping of CD34 subsets reveals unexpected differences between various stem cell sources. Bone Marrow Transplant. 2016 Aug; 51(8):1093-100. View Abstract
54. Relevance of flow cytometric enumeration of post-thaw leucocytes: influence of temperature during cell staining on viable cell recovery. Vox Sang. 2016 Aug; 111(2):187-96. View Abstract
55. An argument for early genomic sequencing in atypical cases: a WISP3 variant leads to diagnosis of progressive pseudorheumatoid arthropathy of childhood. Rheumatology (Oxford). 2016 Mar; 55(3):586-9. View Abstract
56. ABCB5 Identifies Immunoregulatory Dermal Cells. Cell Rep. 2015 Sep 08; 12(10):1564-74. View Abstract
57. Mosaic focal dermal hypoplasia caused by a novel somatic mutation in PORCN detected in affected skin. Br J Dermatol. 2015 Aug; 173(2):568-70. View Abstract
58. Expression of Multidrug Resistance Transporter ABCB5 in a Murine Model of Human Conjunctival Melanoma. Ocul Oncol Pathol. 2015 Apr; 1(3):182-189. View Abstract
59. Restoring the cornea from limbal stem cells. Regen Med. 2015; 10(1):1-4. View Abstract
60. Strong and deep Atlantic meridional overturning circulation during the last glacial cycle. Nature. 2015 Jan 01; 517(7532):73-6. View Abstract
61. ABCB5 is a limbal stem cell gene required for corneal development and repair. Nature. 2014 Jul 17; 511(7509):353-7. View Abstract
62. ABCB5 maintains melanoma-initiating cells through a proinflammatory cytokine signaling circuit. Cancer Res. 2014 Aug 01; 74(15):4196-207. View Abstract
63. The multidrug-resistance transporter ABCB5 is expressed in human placenta. Int J Gynecol Pathol. 2014 Jan; 33(1):45-51. View Abstract
64. Novel double heterozygous mutations in MEFV and NLRP3 genes in a patient with familial Mediterranean fever. J Clin Rheumatol. 2013 Dec; 19(8):452-3. View Abstract
65. Stem cells and targeted approaches to melanoma cure. Mol Aspects Med. 2014 Oct; 39:33-49. View Abstract
66. Genetically determined ABCB5 functionality correlates with pigmentation phenotype and melanoma risk. Biochem Biophys Res Commun. 2013 Jul 05; 436(3):536-42. View Abstract
67. ABCB5 identifies a therapy-refractory tumor cell population in colorectal cancer patients. Cancer Res. 2011 Aug 01; 71(15):5307-16. View Abstract
68. Colorectal Cancer Stem Cells: Biology and Therapeutic Implications. Curr Colorectal Cancer Rep. 2011 Jun; 7(2):128-135. View Abstract
69. VEGFR-1 expressed by malignant melanoma-initiating cells is required for tumor growth. Cancer Res. 2011 Feb 15; 71(4):1474-85. View Abstract
70. Isolation of tumorigenic circulating melanoma cells. Biochem Biophys Res Commun. 2010 Nov 26; 402(4):711-7. View Abstract
71. A novel in vivo regulatory role of P-glycoprotein in alloimmunity. Biochem Biophys Res Commun. 2010 Apr 09; 394(3):646-52. View Abstract
72. Modulation of T-cell activation by malignant melanoma initiating cells. Cancer Res. 2010 Jan 15; 70(2):697-708. View Abstract
73. The therapeutic promise of the cancer stem cell concept. J Clin Invest. 2010 Jan; 120(1):41-50. View Abstract
74. Identification and targeting of cancer stem cells. Bioessays. 2009 Oct; 31(10):1038-49. View Abstract
75. ABCB5 gene amplification in human leukemia cells. Leuk Res. 2009 Oct; 33(10):1303-5. View Abstract
76. Solid tumor stem cells – implications for cancer therapy. Regulatory Networks in Stem Cells. Ed. by V.K. Rajasekhar and M.C. Vemuri. 2009. View Abstract
77. Identification of cells initiating human melanomas. Nature. 2008 Jan 17; 451(7176):345-9. View Abstract
78. Regulation of myogenic progenitor proliferation in human fetal skeletal muscle by BMP4 and its antagonist Gremlin. J Cell Biol. 2006 Oct 09; 175(1):99-110. View Abstract
79. Myogenic potential of muscle side and main population cells after intravenous injection into sub-lethally irradiated mdx mice. J Histochem Cytochem. 2005 Jul; 53(7):861-73. View Abstract
80. ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma. Cancer Res. 2005 May 15; 65(10):4320-33. View Abstract
81. ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma. American Association for Cancer Research 96th Annual Meeting, April 16-20,. 2005. View Abstract
82. Chapter 16: Congentinal, metabolic and neuromuscular disorders in Respiratory Genetics. Ed. By Silverman, Weiss & Shapiro. 2005. View Abstract
83. Differential expression of ABCB5 multidrug resistance P-glycoprotein in human breast cancer cell lines. June 8-11, Abstract P66-7. 2005; 467. View Abstract
84. ABCB5 P-glycoprotein is a molecular marker of the Hoechst 33342 side population phenotype among human fetal skeletal muscle cells. The FASEB Journal (oral presentation). 2004; 18(4):A183. View Abstract
85. Regulation of progenitor cell fusion by ABCB5 P-glycoprotein, a novel human ATP-binding cassette transporter. J Biol Chem. 2003 Nov 21; 278(47):47156-65. View Abstract
86. Regulation of progenitor cell fusion by ABCB5 P-glycoprotein, a novel human ATP-binding cassette transporter. American Journal of Human Genetics. 2003; 73(5 Supplement):327. View Abstract
87. Commitment, differentiation, and diversification of avian cardiac progenitor cells. Ann N Y Acad Sci. 1995; (752):1-8. View Abstract
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